Which type of drugs should be avoided in older adults except in extreme cases due to being on the list of potentially inappropriate medications?

Benzodiazepines are classified as potentially inappropriate medications in older adults due to their adverse effects, which can include sedation, increased risk of falls, cognitive impairment, and dependence. The pharmacokinetics of benzodiazepines can be altered in older individuals, leading to prolonged sedation and stronger cognitive effects, which may exacerbate issues related to balance and mental status. Consequently, their use is generally discouraged unless absolutely necessary, and only under strict medical supervision.

While other medications listed may have considerations in geriatric pharmacotherapy, benzodiazepines stand out due to their high risk of causing significant harm in this population, emphasizing the principle of prescribing with caution to minimize potential risks associated with polypharmacy and adverse drug reactions.